The growth of fluoresence
Laser fluorescence from products such as DIAGNOdent is also becoming more popular, with several products now on the market using this technology to detect demineralization. When this 655 nm diode laser is directed onto a tooth’s surface, its light is absorbed by metabolic byproducts of oral bacteria. These compounds then emit red fluorescence, which is captured by the device and translated into a numerical reading from 0 to 99.
Using the DIAGNOdent doesn’t have the same risks as an explorer, and laser fluorescence has a high sensitivity, meaning it’s accurate in detecting decay, but it has low specificity, meaning that it often produces false negatives. Therefore, laser fluorescence is recommended only as an adjunct device to be used alongside radiographic and clinical evaluation to definitively diagnose decay.5
Similarly, LED fluorescence stimulates metabolic products found in cariogenic bacteria, causing them to glow red, while healthy enamel glows green and shows a visual image on the screen. Other diagnostic tools include near-infrared light, which penetrates enamel deeply through transillumination. Healthy enamel will appear translucent and carious lesions stand out as dark zones.
Other popular diagnostic tools
One exciting innovation that detects demineralization with only ~30–50um of hydroxyapatite loss is BlueCheck, a paint-on diagnostic agent composed of a protein with a high affinity for hydroxyapatite. BlueCheck is a leading indicator, detecting disease earlier than can even be seen visually.
When applied to the tooth surface, BlueCheck helps highlight areas with active demineralization to provide visual cues for clinicians and patients alike. While interproximal detection can be limited, it brings early surface demineralization to light in real time, allowing it to be treated before it becomes a white spot lesion. Check this out in action on Shelley’s dental educational YouTube channel.
Two other cutting-edge disease-indicator tools are LumiCare and Calcivis. LumiCare uses a cavity-detection rinse that contains biocompatible and fluorescent starch nanoparticles that penetrate early-stage, porous enamel lesions. When illuminated with a dental curing light, these particles fluoresce, making incipient caries glow and helping distinguish active demineralization from inactive spots, fluorosis, or hypomineralization.6
The FDA recently approved the tool Calcivis, which employs a special photoprotein spray that lights up in the presence of free calcium from ongoing demineralization. A handheld camera captures this luminescence overlaid on a tooth image, creating a real‑time “demineralization map.” Clinical studies show both tools have excellent accuracy in identifying active demineralization, allowing hygienists to visually confirm disease activity before irreversible damage occurs.
Catching demineralization at its earliest stage
Although several standard‑of‑care caries prevention methods primarily serve as lagging indicators—revealing damage only after demineralization—they still provide essential diagnostic information. This raises two important questions: How early should we aim to detect caries? Which emerging technologies can help us shift from these lagging indicators to true leading indicators that signal demineralization at its earliest stage?
At the foundation of effective caries prevention lies a precise caries risk assessment that accurately classifies a patient’s risk level—low, moderate, or high. For interproximal caries risk detection, CaviSense is a new and intriguing tool. It identifies increased risk with use of a chewable gummy followed by a pH test strip placed interproximally to identify acidic conditions that put teeth at risk.
The gummy acts as a sucrose challenge, introducing sugar to the oral environment to stimulate acid production by bacteria in dental plaque. This process mimics real-life conditions where sugar intake leads to acid generation, which can lower the pH in the mouth.
Determining risk level enables clinicians to tailor interventions appropriately, whether that’s applying fluoride varnish, recommending xylitol, administering probiotics, using silver diamine fluorides or povidone iodine, conducting saliva testing, offering dietary counseling, or deploying innovative agents such as self‑assembling P‑11‑4 peptides.
Hygienists have several options that empower us to not only detect disease but also prevent its progression. Combining risk-based treatment planning with early detection tools and evidence-based remineralization therapies gives us a powerful opportunity to detect lesions before they cavitate, reverse early demineralization, preserve enamel integrity, and break the cycle of repeat restorations and long-term damage. Now, more than ever, we are better equipped to protect our patients’ oral health, and their enamel, for life.
Author’s note: AI tools were used to assist with grammar, spelling, and information retrieval during the development of this article. All content has been reviewed for accuracy and clarity by the author to ensure it meets professional and ethical standards.
References
- Huang TT, Jones AS, He LH, Darendeliler MA, Swain MV. Characterisation of enamel white spot lesions using x-ray micro-tomography. J Dent. 2007;35(9):737-743. doi:10.1016/j.jdent.2007.06.001
- Ekstrand K, Qvist V, Thylstrup A. Light microscope study of the effect of probing in occlusal surfaces. Caries Res. 1987;21(4):368-374. doi:10.1159/000261041
- Ferreira R, Haiter-Neto F, Tabchoury C, Neves de Paiva G, Boscolo F. Assessment of enamel demineralization using conventional, digital, and digitized radiography. Braz Oral Res. 2006;20:(2). doi:10.1590/S1806-83242006000200005
- Onem E, Baksi BG, Sen BH, Soqut O, Mert A. Diagnostic accuracy of proximal enamel subsurface demineralization and its relationship with calcium loss and lesion depth. Dentomaxillofac Radiol. 2012;41(4):285-293. doi:10.1259/dmfr/55879293
- Nokhbatolfoghahaie H, Alikhasi M, Chiniforush N, Khoei F, Safavi N, Zadeh BY. Evaluation of accuracy of DIAGNOdent in diagnosis of primary and secondary caries in comparison to conventional methods. J Lasers Med Sci. 2013;4(4):159-167.
- Amaechi B, Phillips T, Perozo B, et al. Evaluation of a novel caries detecting oral rinse. BDJ Open. March 20, 2023.
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